Battles begin to turn in long war on TB

It kills millions of people and is carried by a quarter of humans, yet there has been just a handful of new drugs in decades and the only vaccine is a century old.

Tuberculosis, a curable and preventable lung infection, killed more than
1.6 million people last year — almost as many as HIV/AIDS and malaria
combined — and is the world’s deadliest infectious disease.

But despite possessing the knowhow to treat it, and even how much it would
cost to eradicate, global efforts to rid humankind of one of its oldest
illnesses lag behind other public health drives.

“TB has been killing millions of people for thousands of years and it’s a
slow-moving disease. You can get infected and never get sick, or not get sick
for decades,” said Ann Ginsberg, senior technical adviser at IAVI, a non-
profit that works on tuberculosis.

“You don’t see it. Even when you get it, you get cough, fever, some night
sweats. It’s not spectacular.”

The World Health Organization says 10 million people developed
tuberculosis in 2017 and global infection rates, while declining, remain
stubbornly high.

But this year has seen several breakthroughs, including trials of a new
vaccine and a pill that shows astonishing success against drug-resistant
forms of the bug, which experts say are cause for optimism.

More than 3000 scientists, activists and disease survivors gathered this
week in The Hague for an annual conference on lung health that was dominated
by advances in the battle against tuberculosis.

Several countries, including South Africa and Belarus showed that a new
drug, bedaquiline, was consistently successful in patients with drug-
resistant tuberculosis — in some cases curing 80 percent.

Adrian Thomas, vice president of global public health at Johnson &
Johnson, which holds the patent on bedaquiline, said the drug could
revolutionise how some TB is treated.

“It means you don’t have the cost of the injectables, you don’t have the
administration, which has to be by a healthcare professional, and you don’t
have the toxicity, but you get the advantages in terms of mortality,” he told
AFP.

Previously, those suffering from multidrug-resistant TB would have to
undergo an eight-month course of excruciating injections, often several times
a day and with severe side effects, including hearing loss in around half of
patients.

“At the end of that process they would often say that dying would be
easier than actually taking the drugs,” said Thomas.

Ahead of a recommendation by the WHO that more multidrug-resistant
patients should receive bedaquiline, this year Johnson & Johnson dropped its
price to $400 (350 euros) per course of treatment.

For Sharonann Lynch, HIV and TB policy advisor at Doctors Without Borders,
that’s still too high. Her organisation wants bedaquiline to cost $1 a day,
half the current price.

“They say they are losing money but one third of the cost goes on funding
to health system strengthening,” she said.

“Why in the world would sick people need to pay for health system
strengthening? That should be the responsibility of governments.”

Thomas said that due to how it is funded and distributed, most people with
access to bedaquiline who need it don’t pay for the treatment themselves.

– Vaccine hope –

Despite its deadliness, there has been just a single widely used vaccine
against TB for nearly 100 years. But this too may be changing.

Last month drugs giant GlaxoSmithKline unveiled a study of a new vaccine
that was effective in 54 percent of trial participants.

It comes with caveats — the trial was only on people in three African
countries who already had tuberculosis but weren’t yet sick from it — and is
in its early stage, but Ginsberg described it as a “turning point”.

Marie-Ange Demoitie, who leads the vaccine development for GSK, said the
eventual aim would be to give it to everyone of a certain age in areas where
TB is prevalent.

“There are several candidate vaccines at the moment but this is the first
time we see a positive signal in a population of adult subjects,” she told
AFP. “It’s really a breakthrough and is bringing a lot of hope to the TB
vaccine field.”

– ‘TB isn’t sexy’ –

Last month UN member states held their first ever summit on tuberculosis
and pledged billions of dollars towards tackling the disease. They aim to
eradicate it within 15 years.

The WHO estimates TB costs the global economy more than $20 billion
annually, nearly half of that going to treating patients.

Ginsberg questioned why more wasn’t being spent on preventing the disease
in the first place.

“Developing a vaccine costs roughly $1 billion over 20 years. So the
investment that’s needed is a small fraction of what we spend on an annual
basis,” she said.

For Kitty van Weezenbeek, executive director of The Hague-based KNCV
Tuberculosis Foundation, TB has been wrongly overlooked in favour of higher
profile diseases.

“TB’s on nobody’s mind. There’s nothing sexy about it,” she said.

“Ten times the research funding is going to HIV. I’m not saying it
shouldn’t go there, the point is it should also come to TB.”